What is the role of a urine calcium study in the workup of organ transplantation-related osteoporosis?

Updated: Jul 02, 2020
  • Author: Carmel M Fratianni, MD, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

A 24-hour urine calcium study may also be considered in the absence of loop diuretic therapy because glucocorticoid administration can be associated with significant hypercalciuria, which is exacerbated by aggressive calcium and vitamin D therapy. [62] In this instance, thiazide diuretics could potentially be considered as a therapeutic strategy because they decrease urine calcium excretion and increase calcium absorption in glucocorticoid-treated patients and may attenuate hip fracture risk. [76, 77, 78]

A low 24-hour urine calcium value could suggest malabsorption or vitamin D deficiency, necessitating higher doses of vitamin D.


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