What is the prevalence of organ transplantation-related osteoporosis?

Updated: Jul 02, 2020
  • Author: Carmel M Fratianni, MD, FACE; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

Low bone mass is extremely common among patients awaiting solid organ transplantation. A large and rapid decrease in bone mineral density (BMD) occurs within the first year following virtually all forms of solid organ transplantation. This decrease in BMD is associated with increased fractures (see the image below). [4, 5, 6] In a large series of abdominal organ and heart transplants from Northwestern University, Ramsey-Goldman et al reported a fracture incidence 5-34 times higher than in historical controls. [7]

Osteoporotic spine. Note the considerable reductio Osteoporotic spine. Note the considerable reduction in overall bone density and the lateral wedge fracture of L2.

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