Which medications in the drug class HMG-CoA reductase inhibitors are used in the treatment of Low HDL Cholesterol (Hypoalphalipoproteinemia)?

Updated: May 21, 2021
  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
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Answer

HMG-CoA reductase inhibitors

Statins are used to lower LDL cholesterol, but they also modestly raise HDL cholesterol.

Atorvastatin (Lipitor)

Selective competitive inhibition of HMG-CoA reductase decreases cholesterol synthesis and increases cholesterol metabolism. Atorvastatin may modestly elevate HDL cholesterol levels. Clinically, reduced levels of circulating total cholesterol, LDL cholesterol, and serum TGs are observed.

Simvastatin (Zocor)

Inhibits HMG-CoA reductase, which, in turn, inhibits cholesterol synthesis and increases cholesterol metabolism.

Pravastatin (Pravachol)

Competitively inhibits HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol synthesis. Before initiating therapy, place patients on a cholesterol-lowering diet for 3-6 mo, and continue the diet indefinitely.

Lovastatin (Mevacor)

Competitively inhibits HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol synthesis. Before initiating therapy, place patients on a cholesterol-lowering diet for 3-6 mo, and continue the diet indefinitely.

Fluvastatin (Lescol)

Synthetically prepared HMG-CoA reductase inhibitor with some similarities to lovastatin, simvastatin, and pravastatin. However, fluvastatin is structurally distinct and has a different biopharmaceutical profile (eg, no active metabolites, extensive protein binding, minimal CSF penetration).

Rosuvastatin (Crestor)

Competitively inhibits HMG-CoA reductase, which catalyzes the rate-limiting step in cholesterol synthesis.

Pitavastatin (Livalo)

HMG-CoA reductase inhibitor (statin) indicated for primary or mixed hyperlipidemia. In clinical trials, 2 mg/d reduced total cholesterol and LDL cholesterol similar to atorvastatin 10 mg/d and simvastatin 20 mg/d.


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