What is the role of cardiac testing in the workup of low HDL cholesterol (hypoalphalipoproteinemia)?

Updated: May 21, 2021
  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
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See the list below:

  • Electrocardiograph (ECG)

    • The 12-lead resting ECG tracings are obtained by placing 6 limb and 6 chest electrodes on the patient.

    • ECG findings consistent with the presence of coronary atherosclerosis may include ST-segment shift or T-wave changes.

  • Exercise (treadmill) stress test

    • The presence of physiologically significant atherosclerotic plaque in 1 or more major coronary arteries may be detected by stressing the heart with continuous ECG monitoring.

    • The patient walks on a treadmill while ECG heart monitoring wires are placed on the chest and tracings are recorded at 2- to 3-minute intervals. The speed and elevation are gradually increased.

    • The treadmill stress test has a predictive accuracy of 60-70%. Sometimes, its readings may be falsely abnormal in people with baseline ECG changes, electrolyte abnormalities, electrical conduction abnormalities, digitalis use, enlarged heart, or mitral valve problems.

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