What are the secondary causes of low HDL cholesterol (hypoalphalipoproteinemia)?

Updated: May 21, 2021
  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
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Secondary causes

  • Obesity

  • Physical inactivity

  • Type 2 diabetes

  • Cigarette smoking

  • End-stage renal disease

  • Hypertriglyceridemia

  • Probucol

  • Androgens

  • Progestins

  • High-dose thiazide diuretics

  • High-dose beta blockers

  • Very low-fat diet

  • Dysglobulinemia

  • Severe liver disease

  • Malabsorption

  • Malnutrition

  • Severe inflammatory disease

Miscellaneous - Data in the literature suggest that some cases of HA involve an increase in thromboxane B2 together with an increased risk of atherosclerosis. Satta and colleagues described a 32-year-old man who revealed clinical and biochemical features strongly indicative of this pathology (see Histologic Findings). [23]

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