Which clinical history findings are characteristic of low HDL cholesterol (hypoalphalipoproteinemia)?

Updated: May 21, 2021
  • Author: Vibhuti N Singh, MD, MPH, FACC, FSCAI; Chief Editor: George T Griffing, MD  more...
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Persons with low high-density lipoprotein (HDL) cholesterol levels, except those patients with a deficiency syndrome, have no symptoms specific to the condition. However, they may have a history of premature atherosclerosis, as well as a history consistent with coronary heart disease (CHD), peripheral artery disease, or other such conditions.

  • Premature atherosclerosis

    • CHD - A history of angina or myocardial infarction (MI) in a person below age 60 years, a history of premature heart disease in a patient's siblings and first-degree relatives, sequelae of MI

    • Congestive heart failure

    • Peripheral vascular disease - A history of claudication

  • Cerebrovascular disease

    • History of stroke

    • History of transient ischemic attack

    • History of carotid endarterectomy

  • Xanthomas (tendinous, cutaneous)

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