What is the efficacy of glyburide in the management of gestational diabetes mellitus (GDM)?

Updated: Apr 29, 2020
  • Author: Thomas R Moore, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

A 2000 randomized trial comparing glyburide to insulin in 404 pregnancies found no difference between the groups in mean maternal blood glucose levels, the percentage of infants who were LGA, birth weights, or neonatal complications. Only 4% of patients in the glyburide study arm required addition of insulin to achieve glucose control. [83] Since this study, several prospective and retrospective studies involving more than 775 pregnancies have concluded glyburide is as safe and effective as insulin. All studies comparing glyburide to traditional insulin have demonstrated similar levels of glycemic control. Most studies show no differences in maternal or neonatal outcomes with glyburide. [85]


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