How can the risk for birth defects associated with gestational diabetes mellitus (GDM) be reduced?

Updated: Apr 29, 2020
  • Author: Thomas R Moore, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

Clinical trials of intensive metabolic care have demonstrated that malformation rates similar to those in the nondiabetic population can be achieved with meticulous preconceptional glycemic control. [31] Subsequent trials comparing a preconceptional intensive metabolic program to standard treatment have demonstrated lowered rates of perinatal mortality (0% vs 7%) and congenital anomalies (2% vs 14%). In addition, when the preconceptional counseling program was discontinued, the congenital anomaly rate increased by over 50%. [34]


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