What is the role of lab studies in the workup of secondary hyperparathyroidism?

Updated: Dec 24, 2020
  • Author: Lawrence T Kim, MD, FACS, FACE; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Serum level of parathyroid hormone, calcium, phosphorus, and 25-hydroxyvitamin D should be measured. Patients with secondary hyperparathyroidism usually have a low-normal calcium and elevated parathyroid hormone. The serum phosphorus level may vary based on the etiology, trending towards higher values with reduced kidney function and lower values with vitamin D deficiency.

Vitamin D deficiency is defined by most experts as a 25-hydroxyvitamin D level of less than 12 ng/mL. A level of 12-20 ng/mL may be considered insufficiency of vitamin D, and a level of 20 ng/mL or greater can be considered to indicate sufficient vitamin D. [56]

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