What is the prevalence of secondary hyperparathyroidism?

Updated: Dec 24, 2020
  • Author: Lawrence T Kim, MD, FACS, FACE; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Vitamin D deficiency has been estimated to affect approximately 40% of US adults, according to data from the National Health and Nutrition Examination Survey (NHANES). [54] . Deficiency of the vitamin in adults has been attributed to decreases in sun exposure, changes in dietary intake, gastrointestinal disorders such as malabsorption syndromes and pancreatic insufficiency, and liver failure with decreased hydroxylation. In CKD, secondary hyperparathyroidism is common and varies based on estimated glomerular filtration rate (eGFR). In milder forms of CKD, elevations in parathyroid hormone levels occur in about 10% of patients, with the prevalence increasing to 90% of individuals with severe CKD who are approaching the need for dialysis therapy. [55]

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