Which medications in the drug class Corticosteroids are used in the treatment of McCune-Albright Syndrome?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Corticosteroids

Glucocorticoids are used for replacement therapy after adrenalectomy for infantile Cushing syndrome.

Mineralocorticoids are used for replacement therapy after adrenalectomy for infantile Cushing syndrome. They act on fluid and electrolyte balance and enhance sodium reabsorption in the kidney, resulting in expanded extracellular fluid volume. They increase renal excretion of potassium and hydrogen ions.

Hydrocortisone (Cortef, Solu-Cortef, A-Hydrocort)

Hydrocortisone is the drug of choice for glucocorticoid replacement because of its mineralocorticoid activity and glucocorticoid effects. A double or triple dose is required for febrile illnesses. Doses as high as 10 times the maintenance level may be needed in the context of severe stress (eg, from trauma, critical illness, or surgery).

Fludrocortisone

Fludrocortisone is used as partial replacement therapy for primary and secondary adrenocortical insufficiency.


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