What is included in the long-term monitoring of precocious puberty in McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Routine monitoring of growth and development is important in the long-term management of individuals with gonadotropin-independent precocious puberty. Careful attention to growth velocity is warranted; early estrogen exposure can inappropriately advance skeletal maturity and decrease adult height potential.

In addition, early estrogen exposure can advance the maturity of the hypothalamic-pituitary-gonadal axis and result in precocious onset of gonadotropin-dependent puberty. Because adult height potential often is already diminished by premature estrogen exposure, consideration should be given to suppression of early onset of puberty to prevent further compromise of adult height.


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