What is the role of surgery in the treatment of hyperthyroidism in McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Ablative therapy (either radioiodine treatment or thyroidectomy) is warranted for the treatment of hyperthyroidism due to MAS. Any cells left behind that contain GNAS1 mutations may result in adenoma formation and recurrence of hyperthyroidism.

Thyroidectomy or hemithyroidectomy is the treatment of choice for hyperthyroidism associated with a goiter in patients with MAS. Partial or total/near-total thyroidectomy may be necessary for the control of thyrotoxicosis or the removal of multiple benign thyroid adenomas (even when they are not hyperfunctioning), progressively increasing goiter, and, of course, the very rare cases of coexisting thyroid carcinoma.


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