What is the role of pharmacologic therapy in the treatment of the endocrine syndromes in McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

In patients with MAS, other identified comorbidities that may be significantly affecting the bone density in a negative way must be identified and aggressively managed. Major morbidities and recommended treatments include the following:

  • Hypogonadism - Appropriate hormone replacement therapy

  • Hypophosphatemia with hyperphosphaturia - Aggressive oral phosphorus replacement

  • Hypophosphatemic rickets - Appropriate calcium supplementation, phosphate repletion, and calcitriol administration

  • Hyperparathyroidism (primary or secondary)


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