What is the role of bone scanning in the workup of McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Asymptomatic sites of FD can be detected with radionuclide (technetium-99m [99m Tc]–labeled methylene diphosphonate) bone scans. On bone scanning, PFD appears as areas of increased activity. This is helpful in defining the extent of disease activity after the diagnosis is made. [42, 43] Finding these sites when gonadotropin-independent precocious puberty is also present can confirm the diagnosis of MAS. The poor specificity of increased patchy bone activity on bone scans precludes their use for screening or exact diagnosis.

Arterial blood gas determination can be performed to evaluate for acidosis, if suspected. Electrocardiography (ECG) can be performed to evaluate for arrhythmia, if suspected. Endoscopy can be performed to evaluate for gastrointestinal (GI) polyposis, if suspected.


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