What is the role of surgery in the treatment of McCune-Albright syndrome (MAS)?

Updated: Jan 05, 2021
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Surgical interventions that may be considered include the following:

  • Precocious puberty – Oophorectomy or ovarian cystectomy, when medical therapy fails

  • PFD – Traction or fixation for fractures; for most PFD lesions, routine removal is not warranted

  • Hyperthyroidism – Thyroidectomy (partial near-total, or total)

  • Infantile Cushing syndrome – Bilateral adrenalectomy

  • Gigantism or acromegaly – Surgical removal of the offending lesion (pituitary adenoma) is rarely curative and is considered only if the tumor is threatening vision (in consultation with an experienced base-of-skull neurosurgeon)

See Treatment and Medication for more detail.

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