How are endocrine abnormalities treated in McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

No long-term effective medical treatment for ACTH-independent Cushing syndrome is available.

Pharmacologic agents that have been used to treat GH excess in MAS include the following:

  • Octreotide

  • Dopamine agonists (eg, bromocriptine and cabergoline), typically in conjunction with octreotide

  • GH receptor antagonists (eg, pegvisomant), probably best not used as monotherapy in this setting

Pharmacologic treatment of other manifestations of MAS is as follows:

  • Hypogonadism - Appropriate hormone replacement therapy

  • Hypophosphatemia with hyperphosphaturia - Aggressive oral phosphorus replacement

  • Hypophosphatemic rickets - Appropriate calcitriol therapy with calcium and phosphate repletion


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