How is precocious puberty treated in McCune-Albright syndrome (MAS)?

Updated: Jan 05, 2021
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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There is no specific treatment for MAS per se. Pharmacologic agents that have been used to treat precocious puberty in MAS include the following:

  • Aromatase inhibitors

  • Gonadotropin-releasing hormone (GnRH) analogues (as adjuncts to aromatase inhibitors)

  • Ketoconazole [6]

  • Estrogen receptor agonists (eg, tamoxifen)

  • Spironolactone

  • Cyproterone acetate

  • Medroxyprogesterone acetate

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