Which lab tests are performed in the workup of McCune-Albright syndrome (MAS)?

Updated: Jan 17, 2019
  • Author: Gabriel I Uwaifo, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Full endocrine studies should be performed. Testicular or ovarian hyperfunction is the most common abnormality. Laboratory studies that may be helpful include the following:

  • Gonadotropin (luteinizing hormone [LH], follicle-stimulating hormone [FSH]) and sex hormone levels

  • Blood and urinary chemistries

  • Thyroid testing (thyroid-stimulating hormone [TSH], thyroxine [T4], antithyroid antibodies)

  • Adrenocorticotropic hormone (ACTH) levels

  • Serum prolactin (PRL)

  • Dexamethasone suppression testing (standard or low-dose/high-dose)

  • Urine collection assayed for free cortisol (urinary free cortisol [UFC])

  • Growth hormone (GH) and insulinlike growth factor 1 (IGF-1) levels

  • Polymerase chain reaction (PCR) assay


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