What is the role of the angiotensin-II infusion test in the workup of primary aldosteronism?

Updated: Mar 24, 2020
  • Author: Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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This test involves evaluating the response of plasma renin activity (PRA) and serum aldosterone (S-Aldo) to a continuous angiotensin-II infusion. The response characteristics are similar to those observed in the posture tests, with an appropriate increase in aldosterone level observed in IAH but not in aldosteronomas.

The angiotensin-II infusion test is much less popular than other aldosteronism tests because it requires continuous infusion and close hemodynamic monitoring, and it is rarely used today.

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