How accurate is NP-59 testing in the workup of primary aldosteronism?

Updated: Mar 24, 2020
  • Author: Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Standard scanning may produce a false-negative result for small aldosteronomas; however, the diagnostic yield can be increased by coadministration of spironolactone. This is the major diagnostic alternative to adrenal venous sampling (AVS).

A retrospective study by Di Martino et al indicated that in select cases, primary aldosteronism can be preoperatively localized using the NP-59 test in place of adrenal venous sampling. Basing the test’s performance on pathologic results, the sensitivity and positive predictive value were 90.9% and 83.3%, respectively; basing the performance on postoperative blood pressure control resulted in a sensitivity and positive predictive value of 91.6% (for both). [33]

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