What are the approach considerations in the workup of primary aldosteronism?

Updated: Mar 24, 2020
  • Author: Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Individuals with primary aldosteronism may present with hypokalemic metabolic alkalosis; however, as many as 38% of patients with primary aldosteronism may be normokalemic at presentation. [15, 21]

Routine laboratory studies can show hypernatremia, hypokalemia, and metabolic alkalosis resulting from the action of aldosterone on the renal distal convoluted tubule (DCT) (ie, enhancing sodium reabsorption and potassium and hydrogen ion excretion). [22]


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