How are the cardiac effects of primary aldosteronism distinguished from the cardiac effects of secondary aldosteronism?

Updated: Mar 24, 2020
  • Author: Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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In a study comparing the cardiac effects of primary versus secondary aldosteronism, Cesari et al determined that while both types of aldosteronism were frequently characterized by left ventricular hypertrophy and diastolic dysfunction, only primary aldosteronism was associated with evident subclinical systolic dysfunction. Moreover, patients with primary aldosteronism had lower heart rates and higher blood pressure and vascular resistance values than did those with the secondary condition, while plasma renin activity was lower in primary than in secondary aldosteronism (0.56 vs 15.00 ng/mL/h, respectively). [16]

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