What are the clinical scenarios in which primary aldosteronism should be considered?

Updated: Mar 24, 2020
  • Author: Gabriel I Uwaifo, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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The clinical presentation of primary aldosteronism is not distinctive, and the correct diagnosis requires a high index of suspicion on the part of the physician. The common clinical scenarios in which the possibility of primary aldosteronism should be considered include the following:

  • Patients with spontaneous or unprovoked hypokalemia, especially if the patient is also hypertensive [15]

  • Patients who develop severe and/or persistent hypokalemia in the setting of low to moderate doses of potassium-wasting diuretics

  • Patients with treatment-refractory/-resistant hypertension (HTN)

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