What is the role of class I NSAIDs in the etiology of cyclooxygenase (COX) deficiency?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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Defined as simple, competitive COX inhibitors, Class I NSAIDs include ibuprofen, piroxicam, naproxen, mefenamic acid, sulindac sulfide, and flufenamic acid. They interact rapidly and reversibly with COX active sites to form an enzyme-inhibitor (EI) complex. Smith and Dewitt determined the inhibitory concentration 50% (IC50) of several class I NSAIDs and observed that an overall higher affinity for the COX-1 isoform exists. [39] However, they emphasized that the relative potency of individual class I NSAIDs may vary between in vitro and in vivo models.

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