What is the role of NSAIDs in the etiology of cyclooxygenase (COX) deficiency?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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Once Vane and colleagues deduced that aspirin and indomethacin inhibited the COX pathway of arachidonate metabolism, numerous investigations were performed to better understand the mechanism by which NSAIDs interacted with COX. [34, 35, 36] Smith and Dewitt explained fundamental differences among the NSAIDs based on their interaction with COX active sites. [37] Consequently, they described 3 distinct classes of inhibitors: class I, II, and III NSAIDs. [38]

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