What is prostaglandin E?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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PGE2 is a significant product of COX in the gastric mucosa, renal medulla, and microvascular endothelium, as well as in some tumors. [13, 14] This biologically active product is converted from PGH2 by endoperoxide-E isomerase. Although the products are structurally related, each functional temperament is curiously diverse. (See the image below.)

Prostaglandin E2 (PGE2). Prostaglandin E2 (PGE2).

In the gastric mucosa, PGE2 preserves integrity by influencing mucus and bicarbonate secretion. [15] It also maintains mucosal blood flow and participates in cellular repair. In the renal medulla, PGE2 enhances vasodilatation and inhibits tubular sodium absorption. [5] Hence, a deficiency of PGE2, as observed in essential hypertension, results in unopposed vasoconstriction.

Further attributes include stimulation of local osteoclasts, relaxation of bronchial smooth muscle tissue, contraction of uterine smooth muscle tissue, and modulation of presynaptic adrenergic neuron receptors. Despite vague interpretation, PGE2 is hypothesized to also be a key participant in local inflammatory responses. [16, 17]

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