What is prostaglandin D?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

PGD2, the predominate product of COX in mast cells, is converted from PGH2 by endoperoxide-D isomerase. Again, the structural characteristics are similar to those of all other prostaglandins. The functional characteristics include symptoms associated with histamine release (eg, hypotension) and poorly defined roles associated with immunologic processes. However, the formation of 9-alpha,11-beta-prostaglandin F (PGF) metabolites by preferential conversion of PGD2 results in the inhibition of platelet aggregation and the contraction of vascular smooth muscle tissue. This might explain the occasional hypertensive patient observed with systemic mastocytosis.


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