What is thromboxane A?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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Answer

Answer

TXA2, the predominate product of COX in platelets and macrophages, is converted from PGH2 by thromboxane synthase. The structural characteristics include a 6-membered ring containing an ether, as depicted in the image below. The functional characteristics include platelet aggregation, vascular smooth muscle constriction, and bronchial smooth muscle constriction with a corresponding 30-second tissue half-life. Furthermore, TXA2 has a different affinity for each eicosanoid-specific receptor because of distinct receptor ligands. As a result, the physiologic responses via TXA2 are tailored to the situation and are less haphazard when stimulated. [12]

Thromboxane A2 (TXA2). Thromboxane A2 (TXA2).

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