What causes cyclooxygenase (COX) deficiency?

Updated: Feb 19, 2019
  • Author: George T Griffing, MD; Chief Editor: George T Griffing, MD  more...
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COX deficiency typically denotes an acquired cause-and-effect relationship between the protein's enzymatic activity and nonsteroidal anti-inflammatory drugs (NSAIDs). However, Nyman and co-investigators, while studying bleeder families on the Aland Islands, reported an autosomal dominant pattern of inheritance for COX deficiency. [2, 3]

In addition, Horellou and colleagues described 3 family members of 2 successive generations with bleeding tendencies and concluded that their platelets were compatible with a COX deficiency. [4] This study also described an autosomal dominant pattern of inheritance but deduced that COX was not imperative to aggregation and adenosine triphosphate (ATP) release in the face of high collagen concentrations. Sporadically documented familial and constitutional bleeding disorders have been associated with platelet COX-1 deficiency.

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