What is the role of direct thrombin inhibitors in deep venous thrombosis (DVT) prophylaxis for patients undergoing orthopedic surgery?

Updated: Jul 25, 2019
  • Author: David A Forsh, MD; Chief Editor: Vinod K Panchbhavi, MD, FACS  more...
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Answer

Answer

In November 2015, the FDA approved dabigatran for prophylaxis of DVT and PE after hip replacement surgery. Approval was based on the RE-NOVATE and RE-NOVATE II trials. [47, 48] Dabigatran was found to have similar effectiveness and safety in preventing VTE following hip arthroplasty as compared with enoxaparin


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