Which combination therapies have been used for deep venous thrombosis (DVT) prophylaxis in patients undergoing orthopedic surgery?

Updated: Jul 25, 2019
  • Author: David A Forsh, MD; Chief Editor: Vinod K Panchbhavi, MD, FACS  more...
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Answer

Keeney and colleagues reported on the use of early mobilization with a combination of IPC and adjusted-dose short-duration warfarin in a group of patients undergoing 700 primary and revision total hip arthroplasties. [36] The investigators recorded a low incidence of clinical DVT (as measured by ultrasonography) on postoperative day 3 or 4 and of clinical DVT and PE within 90 days postoperatively. Further clinical investigations with larger numbers of patients are necessary to determine the optimal levels and duration of anticoagulation with the appropriate risk/benefit ratio.


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