Which medications in the drug class Thrombin Inhibitors are used in the treatment of Venous Thromboembolism (VTE)?

Updated: Nov 05, 2020
  • Author: Vera A De Palo, MD, MBA, FCCP; Chief Editor: Vinod K Panchbhavi, MD, FACS  more...
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Answer

Thrombin Inhibitors

Prevents thrombus development through direct, competitive inhibition of thrombin. Thrombin enables fibrinogen conversion to fibrin during the coagulation cascade.

Dabigatran (Pradaxa)

Inhibits free and clot-bound thrombin and thrombin-induced platelet aggregation. Indicated for prevention of stroke and systemic embolism associated with nonvalvular atrial fibrillation. Also indicated for prevention and treatment of DVT or PE.


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