What causes skin necrosis in patients with venous thromboembolism (VTE)?

Updated: Nov 05, 2020
  • Author: Vera A De Palo, MD, MBA, FCCP; Chief Editor: Vinod K Panchbhavi, MD, FACS, FAOA, FABOS, FAAOS  more...
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Coumarin derivatives can cause skin necrosis as a consequence of widespread subcutaneous microthrombosis. This can occur in individuals who are protein C–deficient, either genetically or owing to large loading doses of a coumarin derivative. Areas usually affected include the breasts, abdominal wall, and lower extremities. [62]

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