What are the contraindications for thrombolytic therapy in the treatment of venous thromboembolism (VTE)?

Updated: Nov 05, 2020
  • Author: Vera A De Palo, MD, MBA, FCCP; Chief Editor: Vinod K Panchbhavi, MD, FACS, FAOA, FABOS, FAAOS  more...
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Absolute contraindications for thrombolysis include the following:

  • Gastrointestinal (GI) bleeding within the past 6 months
  • Active or recent internal bleeding
  • History of hemorrhagic stroke
  • Intracranial or intraspinal disease
  • Recent cranial surgery or head trauma
  • Pregnancy

Relative contraindications include the following:

  • Major surgery or trauma within the past 2 weeks
  • Biopsy within 10 days
  • Other invasive procedures
  • Procedures in a location inaccessible to external compression
  • Uncontrolled coagulation defects such as thrombocytopenia
  • Nonhemorrhagic stroke

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