What are the thrombolytic options for the treatment of venous thromboembolism (VTE)?

Updated: Nov 05, 2020
  • Author: Vera A De Palo, MD, MBA, FCCP; Chief Editor: Vinod K Panchbhavi, MD, FACS, FAOA, FABOS, FAAOS  more...
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Thrombolytic options (for initial treatment of patients with acute, massive PE causing hemodynamic instability) include the following:

  • Tissue plasminogen activator (t-PA; first-choice thrombolytic agent), including the recombinant agents alteplase, reteplase, and tenecteplase
  • Streptokinase (risk of antibody development)
  • Urokinase (of limited availability)

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