Which fibrates are used to treat hypertriglyceridemia (high triglyceride levels)?

Updated: Dec 19, 2019
  • Author: Mary Ellen T Sweeney, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Four fibrates are used clinically: 2 are available in the United States, both in generic formulations: gemfibrozil (Lopid) and fenofibrate (multiple brand names); the other 2 agents, bezafibrate and ciprofibrate, are available in Europe and elsewhere but have not been approved by the US Food and Drug Administration (FDA). Fenofibrate is available in micronized and nonmicronized formulations; no convincing data suggest that one has greater efficacy than the other. Some formulations are better absorbed with food. Relatively recently, the FDA approved a new fenofibrate formulation known as fenofibric acid (Trilipix) with a specific indication for use with a statin in patients with mixed dyslipidemia. [62, 63, 59, 60, 61]


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