What is the frequency of apolipoprotein (apo) E among different racial groups in the US?

Updated: Dec 19, 2019
  • Author: Mary Ellen T Sweeney, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

In black individuals, the frequency of the alleles for apolipoprotein (apo) E2 is 12%; apo E3, 65%; and apoE4, 23%; in the white population, the frequencies are approximately 13%; 76%; and 11%, respectively. [11] The frequency of homology for apo E2 is 1.3%, but because of the necessary "second hit," only about 5% of homologous individuals have overt hyperlipidemia. [11]


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