Which medications may cause hypertriglyceridemia (high triglyceride levels)?

Updated: Jul 23, 2021
  • Author: Mary Ellen T Sweeney, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Medications that can cause hypertriglyceridemia include the following:

  • High-dose thiazide diuretics or chlorthalidone

  • High-dose beta-adrenergic blocking agents, excluding those with intrinsic sympathomimetic activity

  • Unopposed oral estrogen replacement therapy

  • Oral contraceptives with high estrogen content

  • Tamoxifen

  • Glucocorticoids

  • Oral isotretinoin

  • Antiretroviral therapy (including some protease inhibitors, nonnucleoside reverse transcriptase inhibitors)

  • Atypical antipsychotics

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