What is the role of biopsy in the workup of spinal muscle atrophy (SMA)?

Updated: Aug 11, 2020
  • Author: Ashish S Ranade, MBBS, MS, MRCS; Chief Editor: Jeffrey A Goldstein, MD  more...
  • Print
Answer

In patients with SMA, incisional muscle biopsies reveal a uniform smaller diameter of all fibers. This contrasts with biopsy findings for other muscular dystrophies, which consist of degenerating muscle with variable muscle-fiber sizes. Biopsies in patients with hypotonic cerebral palsy reveal normal muscle fibers.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!