What conditions are included in the differential diagnoses of spinal muscle atrophy (SMA) when pseudohypertrophy of the calf is present?

Updated: Aug 11, 2020
  • Author: Ashish S Ranade, MBBS, MS, MRCS; Chief Editor: Jeffrey A Goldstein, MD  more...
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Pseudohypertrophy of the calf is present, which may confound the diagnosis (ie, with Duchenne muscular dystrophy and Becker muscular dystrophy). Bouwsma et al reported that this finding was associated with elevated serum creatine kinase (CK). [26]  This combination was only observed in males; no females in the series had hypertrophy of the calves. [26]

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