What new therapies may be effective in the treatment of frozen shoulder syndrome (FSS) (adhesive capsulitis)?

Updated: Nov 12, 2020
  • Author: Jefferson R Roberts, MD; Chief Editor: S Ashfaq Hasan, MD  more...
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Collagenase clostridium histolyticum (CCH) is an injection treatment that is approved by the US Food and Drug Administration for Dupuytren contracture in adult patients with a palpable cord. An early trial in patients with FSS found that extra-articular injections of CCH were well tolerated and effective compared with exercise. Further investigations will be required to determine whether CCH will become an accepted treatment modality. [78]

A randomized, double-blind, multicenter study, the MEOPA Trial (NCT01087229) has been designed to test the effectiveness of intensive physical therapy. [79]

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