What are predisposing conditions for frozen shoulder syndrome (FSS) (adhesive capsulitis)?

Updated: Nov 12, 2020
  • Author: Jefferson R Roberts, MD; Chief Editor: S Ashfaq Hasan, MD  more...
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Microvascular diseases such as diabetes mellitus may cause abnormal collagen repair, which predisposes patients to FSS. [36] Increased glycosylation of collagen protein and increased formation of abnormal glycation end products and their subsequent accumulation have a detrimental effect on cellular and extracellular processes that might facilitate adhesion and fibrosis. [37] Neovascularization with vascular endothelial growth factor (VEGF) staining has also been identified in diabetic tissue samples. [12]

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