What is the role of matrix metalloproteinases in the pathogenesis of frozen shoulder syndrome (FSS) (adhesive capsulitis)?

Updated: Nov 12, 2020
  • Author: Jefferson R Roberts, MD; Chief Editor: S Ashfaq Hasan, MD  more...
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Answer

Matrix metalloproteinases are involved in the construction of extracellular matrix and in the various cytokines that control collagen deposition. Drugs that inhibit matrix metalloproteinase can induce conditions very similar to FSS and Dupuytren disease. [12]


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