What causes diffuse idiopathic skeletal hyperostosis (DISH)?

Updated: Oct 23, 2018
  • Author: Bruce M Rothschild, MD; Chief Editor: Jeffrey D Thomson, MD  more...
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Answer

Causes are unknown. Diffuse idiopathic skeletal hyperostosis (DISH) is simply a tendency toward calcification of entheses.

Lantsman et al reported that abdominal computed tomography showed significantly more visceral adipose tissue, as well as a significantly higher ratio of visceral to subcutaneous adipose tissue, in 43 patients with DISH as compared with 42 controls. These authors note that visceral adipose tissue is by itself associated with bone proliferation, and suggest that it is potentially a pathogenic pathway for enthesopathic excessive bone production in DISH. [28]


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