What are the NCCN and ESMO treatment guidelines for metastatic osteosarcoma at presentation?

Updated: Jul 01, 2020
  • Author: Charles T Mehlman, DO, MPH; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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NCCN treatment recommendations for metastatic disease at presentation include the following [30] :

  • For resectable metastatic disease (pulmonary, visceral or skeletal), preoperative chemotherapy followed by wide excision of primary tumor; chemotherapy and metastasectomy is also a treatment option
  • For unresectable metastatic disease, chemotherapy with or without radiation therapy; reassess primary site for local control

ESMO-PaedCan-EURACAN recommends that primary metastatic osteosarcoma be treated with a curative intent, following the principles of non-metastatic osteosarcomas. [31]

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