What is the role of genetics in the treatment of osteosarcoma?

Updated: Dec 04, 2018
  • Author: Charles T Mehlman, DO, MPH; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Answer

The genetic roots of cancer are irrefutable, and gene-focused basic science research holds tremendous promise for risk stratification, as well as for effective and innovative treatments. [35] Multidrug-resistant varieties of osteosarcoma are a case in point. [36] These cell lines have been shown to be genetically encoded with a certain membrane-bound glycoprotein that helps render these cancer cells "immune" to many chemotherapeutic agents. Early identification of such patients (perhaps at initial biopsy) would allow a tailored approach to neoadjuvant chemotherapy.


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