What is the role of lab testing in the workup of osteosarcoma?

Updated: Dec 04, 2018
  • Author: Charles T Mehlman, DO, MPH; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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Answer

Most of the laboratory studies that are obtained relate to the use of chemotherapy. It is important to assess organ function before administering chemotherapy and to monitor function after chemotherapy. Important laboratory studies include the following:

  • Lactic dehydrogenase (LDH)
  • Alkaline phosphatase (ALP)
  • Complete blood count (CBC), including differential
  • Platelet count
  • Liver function tests - Aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and albumin
  • Electrolyte levels - Sodium, potassium, chloride, bicarbonate, calcium, magnesium, phosphorus
  • Renal function tests - Blood urea nitrogen (BUN), creatinine
  • Urinalysis

The only blood tests with prognostic significance are LDH and ALP. Patients with an elevated ALP at diagnosis are more likely to have pulmonary metastases. In patients without metastases, those with an elevated LDH are less likely to do well than are those with a normal LDH.


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