What are the survival rates of osteosarcoma?

Updated: Jul 01, 2020
  • Author: Charles T Mehlman, DO, MPH; Chief Editor: Omohodion (Odion) Binitie, MD  more...
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The present understanding of outcome and prognosis for osteosarcoma is driven by certain serum markers, clinical staging, and histologic response to chemotherapeutic agents. [19]

According to SEER data for 1973-2004, the overall relative 5-year survival rates were as follows [17] :

  • Age < 25 years - 61.6% (females, 65.8%; males, 58.4%)
  • Age 25-59 years - 58.7% (females, 64%; males, 54.6%)
  • Age 60-85+ years - 24.2% (females, 27.0%; males, 19.9%), with a drastic drop with advancing age (from ~50% for patients in their 50s to 17% for those in their middle-to-late 60s and to 10.8% for those aged 80 years or older) 

Patients with an elevated ALP at diagnosis are more likely to have pulmonary metastases. In patients without metastases, those with an elevated LDH are less likely to do well than are those with a normal LDH.

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