What is the role of growth hormone in the treatment of osteogenesis imperfecta (OI)?

Updated: Feb 24, 2020
  • Author: Manoj Ramachandran, MBBS, MRCS, FRCS; Chief Editor: Harris Gellman, MD  more...
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Answer

Growth hormone is known to act on the growth plate and also stimulate osteoblast function, possibly via insulinlike growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3. Growth hormone may be beneficial in patients with a quantitative collagen defect, but its role in the management of OI has not been clearly defined.


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